This is the Linux app named WISP to run in Linux online whose latest release can be downloaded as wisp-1.0.zip. It can be run online in the free hosting provider OnWorks for workstations.
Download and run online this app named WISP to run in Linux online with OnWorks for free.
Follow these instructions in order to run this app:
- 1. Downloaded this application in your PC.
- 2. Enter in our file manager https://www.onworks.net/myfiles.php?username=XXXXX with the username that you want.
- 3. Upload this application in such filemanager.
- 4. Start the OnWorks Linux online or Windows online emulator or MACOS online emulator from this website.
- 5. From the OnWorks Linux OS you have just started, goto our file manager https://www.onworks.net/myfiles.php?username=XXXXX with the username that you want.
- 6. Download the application, install it and run it.
WISP to run in Linux online
Ad
DESCRIPTION
UPDATE: LATEST VERSION AT http://git.durrantlab.com//jdurrant/wispAllostery can occur by way of subtle cooperation among protein residues (e.g., amino acids) even in the absence of large conformational shifts. Dynamical network analysis has been used to model this cooperation, helping to computationally explain how binding to an allosteric site can impact the behavior of a primary site often many angstroms away. Traditionally, computational efforts have focused on the most optimal path of correlated motions leading from the allosteric to the primary active site. We present a program called Weighted Implementation of Suboptimal Paths (WISP) capable of rapidly identifying additional suboptimal pathways that may also play important roles in the transmission of allosteric signals. Aside from providing signal redundancy, suboptimal paths traverse residues that, if disrupted through pharmacological or mutational means, could modulate the allosteric regulation of important drug targets.
Audience
Science/Research
User interface
Console/Terminal, Command-line, Plugins
Programming Language
Python, Tcl
This is an application that can also be fetched from https://sourceforge.net/projects/wisp-pathways/. It has been hosted in OnWorks in order to be run online in an easiest way from one of our free Operative Systems.
