This is the Linux app named DACO-algorithm whose latest release can be downloaded as JDACO_1.03.zip. It can be run online in the free hosting provider OnWorks for workstations.
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DACO-algorithm
DESCRIPTION
Eukaryotic gene expression is controlled through molecular logic circuits that combine regulatory signals of many different factors. Complexation of transcription factors and other regulatory proteins is a prevailing and highly conserved mechanism of signal integration within critical regulatory pathways and enable to infer controlled genes as well as the exerted regulatory mechanism.
We developed DACO (domain-aware cohesiveness optimization), a novel algorithm that combines protein-protein interaction networks and domain-domain interaction networks with the cluster-quality metric cohesiveness. The metric is locally maximized on the holistic level of protein interactions while sophisticated connectivity constraints on the domain level are utilized to account for the exclusive and thus inherently combinatorial nature of the interactions within such assemblies.
The original publication can be found on http://bioinformatics.oxfordjournals.org/content/30/17/i415 .
Audience
Science/Research
User interface
Console/Terminal
Programming Language
Python, Java
Categories
This is an application that can also be fetched from https://sourceforge.net/projects/dacoalgorithm/. It has been hosted in OnWorks in order to be run online in an easiest way from one of our free Operative Systems.
